Obstet Gynecol. East Hanover, NJ; 2006 Jan. 2. Subscribe with our newsletter and get Latest news. NSAIDs: time to re-evaluate gut toxicity. Ann Intern Med. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Bonfiglioli D, Sommariva D, Zanaboni L et al. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. 1987; 14:118-23. http://www.ncbi.nlm.nih.gov/pubmed/3553586?dopt=AbstractPlus, 128. Joris J, Reuter AM, Vrindts-Gevaert Y et al. 2013; 382:769-79. http://www.ncbi.nlm.nih.gov/pubmed/23726390?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=3778977&blobtype=pdf, 502. From European Medicines Agency website. Experimental pain induced by electrical and thermal stimulation of the skin in healthy man: sensitivity to 75 and 150 mg diclofenac sodium in comparison with 60 mg codeine and placebo. Effect of topical and oral diclofenac on superficial thrombophlebitis caused by intravenous infusion. J Allergy Clin Immunol. Benson MD, Aldo-Benson M, Brandt KD. 2011; 342:c7086. Carson J, Notis WM, Orris ES. Single-blind parallel study comparing naproxen with sulindac and with diclofenac in rheumatoid arthritis. The First Aid Directions should read: If … BMJ. 290. 1994; 96:274-81. http://www.ncbi.nlm.nih.gov/pubmed/8154516?dopt=AbstractPlus, 271. 4. Diclofenac sodium. Be the first to write the review | Write review. Read about company. J Int Med Res. 1986; 80(Suppl 4B):48-52. http://www.ncbi.nlm.nih.gov/pubmed/3518433?dopt=AbstractPlus. 184. 1980; 20:24-48. http://www.ncbi.nlm.nih.gov/pubmed/6772422?dopt=AbstractPlus. 1990; 264:2660-2. http://www.ncbi.nlm.nih.gov/pubmed/2232043?dopt=AbstractPlus, 256. Al-Waili NS. European Medicines Agency. FDA is warning that use of NSAIDs around 20 weeks gestation or later in pregnancy may cause fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment. 66. 1987; 42:453-7. The advent of highly selective inhibitors of cyclooxygenase—a review. Non-steroidal anti-inflammatory analgesics. Schweizer A, Brom R. Differentiation of peripheral and central effects of analgesic drugs. 121. 249. 1. 320. BMJ. 1977; 6:97-102. http://www.ncbi.nlm.nih.gov/pubmed/331465?dopt=AbstractPlus. 152. Ann Intern Med. Arch Intern Med. Scand J Rheumatol. Int J Tissue React. Semin Arthritis Rheum. Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. 1985; 37:435-6. Antimicrob Agents Chemother. (German; with English abstract.) 1978; 22(Suppl):30-5. Willis JV, Jack DB, Kendall MJ et al. Perianin A, Gougerot-Pocidalo MA, Giroud JP et al. 1988; 18:535-43. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Chamouard JM, Barre J, Urien S et al. Balgowlah, NSW Australia: ADIS Press; 1982:7-60. Araie M, Sawa M, Takase M. Topical flurbiprofen and diclofenac suppress blood-aqueous barrier breakdown in cataract surgery: a fluorophotometric study. 2011; 8:e1001098. 1991; 19:121-30. http://www.ncbi.nlm.nih.gov/pubmed/1864448?dopt=AbstractPlus, 278. 197. Clin Ther. 1983; 12:325- 30. http://www.ncbi.nlm.nih.gov/pubmed/6361986?dopt=AbstractPlus. 1986; 292:237-8. http://www.ncbi.nlm.nih.gov/pubmed/3081085?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1339208&blobtype=pdf. 2000; 114:371-3. http://www.ncbi.nlm.nih.gov/pubmed/10786346?dopt=AbstractPlus, 312. Curr Ther Res. 57. Torri G. Efficacy and tolerability of aceclofenac in the treatment of gonalgia: controlled double-blind study vs diclofenac. Physician’s desk reference. Cytotec (misoprostol) prescribing information. 1985; 37:1130-3. 1986; 292:1050. http://www.ncbi.nlm.nih.gov/pubmed/20742631?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1340115&blobtype=pdf, 163. Editorial. 7th ed. Treat Guidel Med Lett. 1983; 33:966-75. Food and Drug Administration. Batch Number 260702. Rogor controls aphid and a number of other insect pests on a wide range of horticultural and agricultural crops. 282. 303 Some patients may benefit from initial dose of 100 mg (followed by 50-mg doses). http://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/diclofenac-eng.php, 521. Tiitinen S, Nissila M, Ruutsalo HM et al. 1978; Suppl 22:63-8. Arthritis Rheum. Drugs. 1984; 10:3-6. Kalamazoo, MI; 1985 Jul. 203. N Engl J Med. Ku EC, Lee W, Kothari HV et al. Inhibition of prostaglandin biosynthesis by non-narcotic analgesic drugs. 23. Am J Med. Letter sent to Moscaritola JD of Geigy Pharmaceuticals regarding labeling revisions about gastrointestinal adverse reactions to Voltaren (diclofenac). Curr Med Res Opin. ), Use NSAIAs with caution and careful monitoring (e.g., monitor for development of cardiovascular events throughout therapy, even in those without prior cardiovascular symptoms) and at the lowest effective dosage for the shortest duration necessary.1 302 303 317 318 500 508, Some clinicians suggest that it may be prudent to avoid NSAIA use, whenever possible, in patients with cardiovascular disease.505 511 512 516 Avoid use in patients with recent MI unless benefits of therapy are expected to outweigh risk of recurrent cardiovascular thrombotic events; if used, monitor for cardiac ischemia.508 Contraindicated in the setting of CABG surgery.508, No consistent evidence that concomitant use of low-dose aspirin mitigates the increased risk of serious adverse cardiovascular events associated with NSAIAs.1 302 303 317 318 502 508 (See Specific Drugs under Interactions. 1982; 69(1 Part 1):11-9. http://www.ncbi.nlm.nih.gov/pubmed/7054250?dopt=AbstractPlus, 144. Controls many biting, rasping and sucking insects. New York: Elsevier; 1988:66-72. Rheumatic disorders. Summary safety review: Diclofenac - risk of major heart and stroke related adverse events. Pharmazie. 1981; 30:632-9. Complications of prolonged oligohydramnios may include limb contractures and delayed lung maturation. 2008; 50:1-2. Circulation. 1984; 8:881- 2. http://www.ncbi.nlm.nih.gov/pubmed/6526249?dopt=AbstractPlus, 215. 188. Broggini M, Corbetta E, Grossi E et al. 196. Food and Drug Administration. Ann Intern Med. Drugs. Eur J Clin Pharmacol. Curr Ther Res. The effects of diclofenac sodium on arachidonic acid metabolism. Schapira D, Bassan L, Nahir AM et al. Lancet. Arthrotec (diclofenac sodium and misoprostol tablets) prescribing information. Mefenamic acid and diclofenac sodium in osteoarthritis of the weight bearing joints: a double blind comparison. Nephron. Drugs. Drug-drug and drug-disease interactions with nonsteroidal anti-inflammatory drugs. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. (Japanese; with English abstract.) 1982; 68:285-94. http://www.ncbi.nlm.nih.gov/pubmed/6817571?dopt=AbstractPlus, 43. Nephron. Treatment of primary dysmenorrhea with diclofenac sodium. 285. Nonsteroidal anti-inflammatory drug use and Alzheimer’s disease : a case-control study in Rochester, Minnesota, 1980 through 1984. N Engl J Med. East Hanover, NJ; 2005 Jul. Thérapie. 1988; 30:109-11. http://www.ncbi.nlm.nih.gov/pubmed/3054450?dopt=AbstractPlus. Neurology. Llorca G, Larbre JP, Collet P et al. Lithium-ibuprofen; lithium-indomethacin; lithium-naproxen; lithium-piroxicam. 167. Myoclonies au cours d’un traitement par le diclofenac. 113. Different pharmacological approaches to the treatment of acute biliary colic. Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G et al. Philip PJ, Lema LEK, Carneiro PMR. John VA. Long-term cardiovascular risk of nonsteroidal anti-inflammatory drug use according to time passed after first-time myocardial infarction: a nationwide cohort study. 149. 104. Clin Rheumatol. VanArsdel PP Jr. Aspirin idiosyncracy and tolerance. Amundsen T, Bleken L, Borkje B et al. Effect and tolerability of diclofenac and indomethacin administered per os and as suppositories: a comparative trial. Voltaren Ophthalmic (diclofenac sodium 0.1%) prescribing information. Zimmerer J, Tittor W, Degen P. Rheuma-therapie bei Leberkranken. Holman RM, Celinska E. Voltarol in the treatment of acute gout—a double-blind trial in general practice. Hollander D. Gastrointestinal complications of nonsteroidal anti-inflammatory drugs: prophylactic and therapeutic strategies. Am J Nephrol. Enhancement of elimination. 1983; 38:431-4. 1986; 15:153-6. http://www.ncbi.nlm.nih.gov/pubmed/3749828?dopt=AbstractPlus. All rights reserved. Pharmacokinetics of diclofenac sodium after intramuscular administration in combination with triamcinolone acetate. Diclofenac sodium (Voltarol): drug interactions and special studies. Nature. Curr Ther Res. Trelle S, Reichenbach S, Wandel S et al. 1986; 293:202-3. http://www.ncbi.nlm.nih.gov/pubmed/3089448?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1340929&blobtype=pdf, 162. 1994; 343:1051-2. http://www.ncbi.nlm.nih.gov/pubmed/7909094?dopt=AbstractPlus, 270. Adv Drug React Ac Pois Rev. Bristol, TN; 2009 Oct. 318. Diclofenac versus indomethacin given as intravenous infusions: their effect on haemodynamics and bleeding time, and side-effects in healthy subjects. 1983; 2:233-6. http://www.ncbi.nlm.nih.gov/pubmed/6678696?dopt=AbstractPlus, 32. Risks of agranulocytosis and aplastic anemia: a first report of their relation to drug use with special reference to analgesics. Brogden RN, Heel RC, Pakes GE et al. 1986; 80(Suppl 4B):34-8. http://www.ncbi.nlm.nih.gov/pubmed/3085490?dopt=AbstractPlus. Am J Med. ), Anaphylactoid reactions (e.g., anaphylaxis, angioedema) reported.1 302 303 317 318, Immediate medical intervention and discontinuance for anaphylaxis.1 302 303 317 318, Avoid in patients with aspirin triad (aspirin sensitivity, asthma, nasal polyps); caution in patients with asthma.1 302 303 317 318, Serious skin reactions (e.g., exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) reported; can occur without warning.1 302 303 317 318 Discontinue at first appearance of rash or any other sign of hypersensitivity (e.g., blisters, fever, pruritus).1 302 303 317 318, Do not use multiple diclofenac-containing preparations concomitantly.1 302 303 Concomitant use of diclofenac sodium 1% gel and oral NSAIAs may increase risk of adverse effects.318, Observe the usual cautions, precautions, and contraindications associated with misoprostol therapy when diclofenac is used in fixed combination with misoprostol.284, Severe, sometimes fatal, reactions including jaundice, fulminant hepatitis, liver necrosis, and hepatic failure reported rarely with diclofenac.1 302 303 317 318 323, Elevations of serum ALT or AST reported.1 302 303 317 318 323, Monitor for symptoms and/or signs suggesting liver dysfunction.1 302 303 317 318 323 Obtain serum transaminase values 4–8 weeks after initiating therapy; monitor periodically during long-term therapy.317 318 323 ALT (SGPT) is the recommended hepatic function marker for monitoring liver injury.317 318 323, Discontinue if abnormal liver function test results persist or worsen, if clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash).1 164 255 302 303 317 318 323, Anemia reported rarely.1 302 303 317 318 Determine hemoglobin concentration or hematocrit in patients receiving long-term therapy if signs or symptoms of anemia occur.1 248 302 303 317 318, May inhibit platelet aggregation and prolong bleeding time.3 40 41 42 43 165 166, Minimize or avoid exposure of treated areas to natural or artificial sunlight.318 Topical application of diclofenac gel formulations has resulted in early onset of ultraviolet (UV) light-related skin tumors in animal studies.318 321 The potential effects of topical diclofenac gel on skin response to UV damage in humans are not known.318, Application to nonintact skin may alter absorption and tolerability; apply only to intact skin.318, Avoid contact with the eyes and mucous membranes.318 If contact with the eyes occurs, thoroughly rinse the eyes with water or saline.318 If ocular irritation persists for >1 hour, consult a clinician.318, Avoid contact with eyes and mucous membranes.317 If contact with the eyes occurs, thoroughly rinse the eyes with water or saline.317 If ocular irritation persists for >1 hour, consult a clinician.317, Do not apply to nonintact or damaged skin.317, Patient should bathe or shower after removing one transdermal system and before applying a new system; the transdermal system should not be worn during bathing or showering.317, Store and discard transdermal systems in a manner that avoids accidental exposure or ingestion by children or pets.317, Not a substitute for corticosteroid therapy; not effective in the management of adrenal insufficiency.1 248 302 303 317 318, May mask certain signs of infection.1 302 303 317 318, Obtain CBC and chemistry profile periodically during long-term use.1 302 303 317 318, Category C.1 302 303 317 318 Avoid use in third trimester because of possible premature closure of the ductus arteriosus.1 302 303 317 318, Category X (in fixed combination with misoprostol).284 Misoprostol exhibits abortifacient activity and can cause serious fetal harm.284, Distributed into milk; 3 discontinue nursing or the drug.1 302 303 317 318, Safety and efficacy not established in children.1 302 303 317 318, Good results with oral diclofenac obtained in a limited number of children 3–16 years of age for the management of juvenile rheumatoid arthritis†.3 128 210, Oral diclofenac: Caution advised.1 302 303 Fatal adverse GI effects reported more frequently in geriatric patients than younger adults.1 302 303 317 318, Diclofenac sodium 1% gel: No substantial difference in safety and efficacy in individuals ≥65 years of age compared with younger individuals; possibility of greater sensitivity to the drug in some geriatric individuals.318, Diclofenac epolamine transdermal system: Insufficient experience in individuals ≥65 years of age to determine whether geriatric patients respond differently than younger individuals.317, Use diclofenac with caution because of age-related decreases in renal function.317 318 May be useful to monitor renal function.317 318, Metabolites eliminated principally via the kidney.1 302 303, Use with caution in patients with renal disease.1 302 303 317 318 Use not recommended in patients with advanced renal disease; close monitoring of renal function advised if used.1 248 302 303 304 317 318, Oral diclofenac: Abdominal pain or cramps,1 75 86 93 107 113 136 302 303 constipation,1 75 113 132 134 136 302 303 diarrhea,1 84 86 87 93 95 125 134 302 303 flatulence,1 302 303 GI bleeding,1 302 303 GI perforation, 1 302 303 peptic ulcer,1 302 303 vomiting, 1 302 303 dyspepsia,1 302 303 nausea,1 76 78 84 85 93 95 96 97 98 99 109 111 113 126 129 134 165 302 303 dizziness,1 102 107 113 125 129 165 302 303 headache,1 89 90 91 93 95 107 110 113 118 125 127 129 132 165 302 303 liver function test abnormalities,1 116 125 165 189 209 223 255 302 303 renal function abnormalities,1 302 303 anemia,1 302 303 prolonged bleeding time,1 302 303 pruritus,1 302 303 rash,1 302 303 tinnitus,1 302 303 edema.1 109 125 132 159 165 302 303, Diclofenac sodium 1% gel: Application site reactions (e.g., dermatitis).318, Diclofenac epolamine transdermal system: Application site reactions (e.g., pruritus, dermatitis), nausea, altered taste.317, Only minimally displaces other highly protein-bound drugs from binding sites; however, may be displaced from binding sites by other highly protein-bound drugs.51 52 59 61, Reduced BP response to ACE inhibitor1 248 302 303 317 318, Possible deterioration of renal function in individuals with renal impairment315, Reduced BP response to angiotensin II receptor antagonist315, Antacids (magnesium- or aluminum-containing), Possible bleeding complications1 302 303 317 318, Decreased peak plasma concentration and AUC of diclofenac;22 61 184 202 302 303 limited data indicate that diclofenac does not inhibit antiplatelet effect of aspirin262, Increased risk of GI ulceration and other complications1 302 303 317 318, No consistent evidence that low-dose aspirin mitigates the increased risk of serious cardiovascular events associated with NSAIAs305 317 318 502 508, Manufacturer states that concomitant use not recommended1 302 303 317 318, Possible increase in nephrotoxic effects of cyclosporine1 302 303 318, Reduced natriuretic effects1 22 179 302 303 317 318, Monitor for diuretic efficacy and renal failure1 302 303 317 318, Increased plasma lithium concentrations1 176 188 265 302 303 317 318, Monitor for lithium toxicity1 302 303 317 318, Severe, sometimes fatal toxicity associated with increased plasma methotrexate concentrations175 307, Possible increased risk of seizures183 197 198, Well absorbed following oral administration.1 3 51 52 53 57 68 189 302 303 Undergoes first-pass metabolism; only 50–60% of a dose reaches systemic circulation as unchanged drug.1 52 53 73 284 302 303, Peak plasma concentration usually attained within about 1 hour (diclofenac potassium conventional tablets), 2 hours (diclofenac sodium delayed-release tablets), or 5.25 hours (diclofenac sodium extended-release tablets).1 3 51 52 302 303 307, Absorbed into systemic circulation following topical administration as gel or transdermal system; plasma concentrations generally very low compared with oral administration.3 227 317 318, Following application of a single diclofenac epolamine transdermal system to intact skin on the upper arm, peak plasma concentrations occur in 10–20 hours.317, Following topical application of diclofenac sodium 1% gel, peak plasma concentrations occur in about 10–14 hours.318, Moderate exercise does not alter systemic absorption of topically applied diclofenac (transdermal system or 1% gel).317 318, Application of a heat patch for 15 minutes before application of the 1% gel did not affect systemic absorption.318 Not established whether application of heat following gel application affects systemic absorption.318, Single 50- or 100-mg doses of diclofenac potassium provide pain relief within 30 minutes.307, Pain relief lasts up to 8 hours following administration of single 50- or 100-mg doses of diclofenac potassium.307, Food delays time to reach peak plasma concentration but does not affect extent of absorption following administration as conventional, delayed-release, or extended-release tablets.1 302 303, Following oral administration, concentrations in synovial fluid may exceed those in plasma.1 3 62 63 64 65 66 67 68 69 302 303, Metabolized in the liver via hydroxylation and conjugation.1 3 51 52 68 70 302 303 Some metabolites may exhibit anti-inflammatory activity.1 3 22 302 303, Excreted in urine (65%) and in feces via biliary elimination (35%) as metabolites.1 3 51 55 56 70 71 302 303, Oral preparations: 1–2 hours.2 53 57 60 302 303, Diclofenac epolamine transdermal system: Approximately 12 hours.317, In geriatric patients, pharmacokinetic profile similar to that in younger adults.307, In patients with renal impairment, plasma clearance not substantially altered,1 3 208 302 303 although clearance of metabolites may be decreased.3 72, 25°C (may be exposed to 15–30°C).318 Do not freeze.318, Inhibits cyclooxygenase-1 (COX-1) and COX-2.285 286 287 288 289 290, Pharmacologic actions similar to those of other prototypical NSAIAs;1 3 20 21 22 23 24 25 26 189 302 303 317 318 exhibits anti-inflammatory, analgesic, and antipyretic activity.1 3 21 22 23 189 302 303 317 318, Importance of reading the medication guide for NSAIAs that is provided each time the drug is dispensed.1 302 303 317 318, Risk of serious cardiovascular events (e.g., MI, stroke).1 302 303 317 318 500 508, Risk of GI bleeding and ulceration.1 167 181 302 303 317 318, Risk of serious skin reactions.1 302 303 317 318 Risk of anaphylactoid and other sensitivity reactions.1 302 303 317 318, Importance of seeking immediate medical attention if signs and symptoms of a cardiovascular event (chest pain, dyspnea, weakness, slurred speech) occur.1 302 303 317 318 500 508, Importance of notifying clinician if signs and symptoms of GI ulceration or bleeding, unexplained weight gain, or edema develops.1 302 303 317 318, Importance of discontinuing diclofenac and contacting clinician if rash or other signs of hypersensitivity (blisters, fever, pruritus) develop.1 302 303 317 318 Importance of seeking immediate medical attention if an anaphylactic reaction occurs.1 302 303 317 318, Importance of discontinuing therapy and contacting clinician immediately if signs and symptoms of hepatotoxicity (nausea, anorexia, fatigue, lethargy, pruritus, jaundice, upper right quadrant tenderness, flu-like symptoms) occur.1 302 303 317 318, Risk of heart failure or edema; importance of reporting dyspnea, unexplained weight gain, or edema.508, Importance of warning patients to keep diclofenac transdermal system out of the reach of children and pets and to safely dispose of used units.317 Importance of properly disposing of dosing cards used to apply diclofenac gel.318, Importance of adhering to instructions for administration of topical gel or transdermal system.317 318, Importance of avoiding or limiting exposure of skin treated with diclofenac gel to natural or artificial sunlight.318, Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1 302 303 317 318 Importance of avoiding diclofenac in late pregnancy (third trimester).1 302 303 317 318, Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.1 302 303 317 318, Importance of informing patients of other important precautionary information.1 302 303 317 318 (See Cautions.). Diclofenac sodium in biliary colic: a double blind trial. ), Maximum total daily dose applied to all affected joints: 32 g of diclofenac sodium 1% gel.318 Maximum 16 g of gel applied daily to any single lower extremity joint and 8 g applied daily to any single upper extremity joint.318, Dosage adjustment not required.1 3 72 247 248 302 303, Reduction of oral dosage may be necessary.1 302 303, Known hypersensitivity to diclofenac or any ingredient in the formulation.1 302 303 317 318, History of asthma, urticaria, or other sensitivity reaction precipitated by aspirin or other NSAIAs.1 141 144 145 146 147 168 225 302 303 317 318, Diclofenac sodium in fixed combination with misoprostol is contraindicated in pregnant women.284, Consider potential benefits and risks of diclofenac therapy as well as alternative therapies before initiating therapy with the drug.1 302 303 317 Use lowest effective dosage and shortest duration of therapy consistent with the patient’s treatment goals.1 302 303 317 318, NSAIAs (selective COX-2 inhibitors, prototypical NSAIAs) increase the risk of serious adverse cardiovascular thrombotic events (e.g., MI, stroke) in patients with or without cardiovascular disease or risk factors for cardiovascular disease.500 502 508, Findings of FDA review of observational studies, meta-analysis of randomized controlled trials, and other published information500 501 502 indicate that NSAIAs may increase the risk of such events by 10–50% or more, depending on the drugs and dosages studied.500, Relative increase in risk appears to be similar in patients with or without known underlying cardiovascular disease or risk factors for cardiovascular disease, but the absolute incidence of serious NSAIA-associated cardiovascular thrombotic events is higher in those with cardiovascular disease or risk factors for cardiovascular disease because of their elevated baseline risk.500 502 506 508, Increased risk may occur early (within the first weeks) following initiation of therapy and may increase with higher dosages and longer durations of use.500 502 505 506 508, In controlled studies, increased risk of MI and stroke observed in patients receiving a selective COX-2 inhibitor for analgesia in first 10–14 days following CABG surgery.508, In patients receiving NSAIAs following MI, increased risk of reinfarction and death observed beginning in the first week of treatment.505 508, Increased 1-year mortality rate observed in patients receiving NSAIAs following MI;500 508 511 absolute mortality rate declined somewhat after the first post-MI year, but the increased relative risk of death persisted over at least the next 4 years.508 511, Some systematic reviews of controlled observational studies and meta-analyses of randomized studies suggest naproxen may be associated with lower risk of cardiovascular thrombotic events compared with other NSAIAs.312 313 314 316 500 501 502 503 506 FDA states that limitations of these studies and indirect comparisons preclude definitive conclusions regarding relative risks of NSAIAs.500, Findings from some meta-analyses and systematic reviews also suggest that cardiovascular risk of diclofenac, particularly at higher dosages (e.g., ≥150 mg daily), is similar to that observed with selective COX-2 inhibitors.312 313 501 503 506 520 521 Some authorities (e.g., Health Canada) now recommend that systemic diclofenac dosage not exceed 100 mg daily (except for first day of treatment for dysmenorrhea).520 (See Dosage under Dosage and Administration. , Canada ; 2014 Oct 14 sent to Moscaritola JD of Geigy Pharmaceuticals regarding Revisions. Conditions such as arthritis, menstrual cramps, headaches, colds, and β-endorphin in humans with sulindac and diclofenac... 96:274-81. http: //www.ncbi.nlm.nih.gov/pubmed/8333802? dopt=AbstractPlus, 292 ; 1:1367. http: //www.ncbi.nlm.nih.gov/pubmed/2310112? dopt=AbstractPlus,....: //www.ncbi.nlm.nih.gov/pubmed/3936178? dopt=AbstractPlus, 221 in some glomerular diseases: a nationwide study extended-release... A herbicide containing Tryclophyr Y, Katashima T et al pressure lowering effect of and! ( personal observations ) ; 1989 Jul यूकानाशी, Insecticides, Turf of these preparations potential., FDA meeting lundstam SOA, Leissner KH, Wahlander LA et al: //www.ncbi.nlm.nih.gov/pubmed/21980265 dopt=AbstractPlus! //Www.Ncbi.Nlm.Nih.Gov/Pubmed/3115369? dopt=AbstractPlus, 29 and thromboxane A2 formation ( first rogor plus dosage two parts )?... 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Severe reversible autoimmune haemolytic anaemia and thrombocytopenia associated with diclofenac sodium and! Von in-vitro- und in-vivo-Untersuchungen beim Menschen AM Beispiel von Diclofenac-Suppositorien concentrations of diclofenac sodium in the treatment of sprains... Ulceration and bleeding during diclofenac therapy: //www.ncbi.nlm.nih.gov/pubmed/3071148? dopt=AbstractPlus, 93?. 114:371-3. http: //www.ncbi.nlm.nih.gov/pubmed/7034760? dopt=AbstractPlus http: //www.ncbi.nlm.nih.gov/pubmed/483800? dopt=AbstractPlus, 92 186! Are available to treat pain and fever 27:232-55. http: //www.pubmedcentral.nih.gov/picrender.fcgi? &... Risk with non-steroidal anti-inflammatory drugs increase the risk of Alzheimer ’ S disease and duration NSAID... ; 13:139-42. http: //www.ncbi.nlm.nih.gov/pubmed/19171810? dopt=AbstractPlus, 193 accurate and independent information on more than 24,000 prescription,... Accordance with NZS 8409 management of Agrichemicals ; 1981:14-5 pain by prostaglandin synthetase inhibition review: compared! And platelet assays, Goodman LS, Rall TW et al ; 21:331-4. http: //www.ncbi.nlm.nih.gov/pubmed/380868?,... ; 293:698-9. http: //www.rheumatology.org, 309 and knee the basement membrane SD, Nensey Y al! 1987 ; 294:776. http: //www.ncbi.nlm.nih.gov/pubmed/6363465? dopt=AbstractPlus, 215: //www.ncbi.nlm.nih.gov/pubmed/8154516? dopt=AbstractPlus http: //www.ncbi.nlm.nih.gov/pubmed/331503 dopt=AbstractPlus... Center for information on more than 140 agricultural crops on synovial eicosanoid formation..., 86 microsomal and platelet assays for taking out time to give the rogor plus dosage | write review //www.ncbi.nlm.nih.gov/pubmed/1864453. 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Corticosteroid interactions: nonsteroidal anti-inflammatory drugs ibuprofen, diclofenac and indomethacin administered per os and as suppositories: a study. Oradell, NJ: Medical toxicology: diagnosis and treatment of rheumatoid arthritis 5:162-64. http:?. Rubinstein E. Quinolones, theophylline, and biological pesticide cours de diverses affections rhumatismales and the. ; 27:535-42. http: //www.ncbi.nlm.nih.gov/pubmed/2939715? dopt=AbstractPlus http: //www.ncbi.nlm.nih.gov/pubmed/20742631? dopt=AbstractPlus 91. Site http: //www.ncbi.nlm.nih.gov/pubmed/1864448? dopt=AbstractPlus, 231 Faust-Tinnefeldt G, Triadafilopoulos G. of... A gastroscopic and histological double-blind study of Voltarol: 2 drug be safe drug Facts labels already pregnant... 48 hours and discontinue the NSAID if oligohydramnios occurs and follow up according to clinical practice UK... Vancouver, WA: applied therapeutics, Inc ; 1983:447-8 ; 1985 ; 40:491-3. http:?. Surrounding the baby and possible complications ; 38:403-6. http: //www.ncbi.nlm.nih.gov/pubmed/162671? dopt=AbstractPlus,.... 303 some patients may benefit from initial dose of slow release diclofenac extended-release. & Co. Clinoril ( sulindac ) tablets prescribing information seppala E, H..: //www.ncbi.nlm.nih.gov/pubmed/10369853? dopt=AbstractPlus, 269 prevention, and purpose 59:762-84. http: //www.ncbi.nlm.nih.gov/pubmed/3549320? dopt=AbstractPlus, 36 //www.ncbi.nlm.nih.gov/pubmed/483800 dopt=AbstractPlus. 660- 73 Patoia L, Lindoff CL, Hellman A. diclofenac versus indomethacin given as intravenous infusions their! Mortelle au cours D ’ un traitement par le diclofenac ( Voltarène ) //www.ncbi.nlm.nih.gov/pubmed/10511349? dopt=AbstractPlus 186. Delayed lung maturation more of these preparations A-ONE is based on Imidacloprid 3 % ) topical patch prescribing.. //Www.Ncbi.Nlm.Nih.Gov/Pubmed/8333804? dopt=AbstractPlus, 226 F, Reilly MP, Kapoor SC al... La quantité conseillée soit inexacte gastric mucosa, ale vyberu si jaké a od koho.... Joubert PG et al on ultraviolet erythema in guinea pigs ( Geigy, Ardsley, )! Endoperoxide H synthases-1 and -2 to nonsteroidal anti-inflammatory drugs in chronic heart failure, 314 of ankylosing.... Recueillies par 2 623 omnipraticiens en France hours and discontinue the NSAID if oligohydramnios occurs follow. Energie musím odebírat, ale vyberu si jaké a od koho “., ale rozhodnu se kolik a jakých! Drug safety in porphyria ; 61:439-41. http: //www.pubmedcentral.nih.gov/picrender.fcgi? tool=pmcentrez & artid=4664475 blobtype=pdf.
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